In some ways, it's similar to the Atkins diet, which similarly boosts the body's fat-burning abilities through eating only low-carb foods, along with getting rid of foods high in carbs and sugar. Removing glucose from carbohydrate foods will cause the body to burn fat for energy instead. The major differences between the classic keto diet and the Atkins diet is ketogenic emphasizes healthier fats, less overall protein and no processed meat (such as bacon) while having more research to back up its efficacy.

Other experts say the long-term accumulation of ketones could be harmful. œThose ketones are emergency fuel sources, and we're not meant to run on them long-term, says Kristen Kizer, a registered dietitian at Houston Methodist Hospital. œKetones are negatively-charged molecules, which means they're acidic. When you build up ketone bodies in your system, you're building up acid. One of the ways your body buffers acid is by pulling calcium from your bones. Kizer also notes that the diet isn't very balanced and involves a very high intake of animal products, which generally do not protect against cancer, diabetes, or other diseases.


Certain studies suggest that ketogenic diets may œstarve cancer cells. A highly processed, pro-inflammatory, low-nutrient diet can feed cancer cells causing them to proliferate. What's the connection between a high-sugar diet and cancer? The regular cells found in our bodies are able to use fat for energy, but it's believed that cancer cells cannot metabolically shift to use fat rather than glucose. (11)
Gary D. Foster, Ph.D., Holly R. Wyatt, M.D., James O. Hill, Ph.D., Brian G. McGuckin, Ed.M., Carrie Brill, B.S., B. Selma Mohammed, M.D., Ph.D., Philippe O. Szapary, M.D., Daniel J. Rader, M.D., Joel S. Edman, D.Sc., and Samuel Klein, M.D., œA Randomized Trial of a Low-Carbohydrate Diet for Obesity ” NEJM, N Engl J Med 2003; 348:2082- 2090. http://www.nejm.org/doi/full/10.1056/NEJMoa022207.
The Atkins diet, on the other hand, is solely focused on weight loss. There is no restriction on artificial sweeteners or manufactured foods, as long as the foods consumed fit the Atkins prescribed ratios. There are four phases to the Atkins diet. The first phase is the most strict, designed to get you into ketosis. The second phase is a tolerance testing phase, where you add more foods to see how many grams of carbohydrate you can still eat and lose weight. The third phase is more generous with carbs, and the fourth phase is the most generous, and it's in either the third or fourth phase that most people find a good maintenance level.
It's important to remember that the goal of any dietary change is to promote a healthy lifestyle, so make sure to select a meal plan you can envision yourself following long term. If you know you will not be able to comply with such stringent carbohydrate restrictions for years to come, the ketogenic diet is most likely not the right choice for you.

Certain studies suggest that ketogenic diets may œstarve cancer cells. A highly processed, pro-inflammatory, low-nutrient diet can feed cancer cells causing them to proliferate. What's the connection between a high-sugar diet and cancer? The regular cells found in our bodies are able to use fat for energy, but it's believed that cancer cells cannot metabolically shift to use fat rather than glucose. (11)


Net carbs are what we track when following a ketogenic diet. This calculation is pretty straightforward. Net Carbs = Total Carbs “ Fiber. For example, one cup of broccoli has 6g of total carbs and 2.4g of fiber. That would mean one cup of broccoli has 3.6g of net carbs. We count Net Carbs because dietary fiber does not have a significant metabolic effect.

The ketogenic diet is super high in fat (about 80 percent of your daily calories), super low in carbohydrates (less than 5 percent of your calories), and moderate in protein (typically 15 to 20 percent of your calories). This is a pretty drastic departure from the generally recommended macronutrient distribution of 20 to 35 percent protein, 45 to 65 percent carbohydrates, and 10 to 35 percent fat.


Sharon M. Nickols-Richardson, PhD, RD, , Mary Dean Coleman, PhD, RD, Joanne J. Volpe, Kathy W. Hosig, PhD, MPH, RD, œPerceived Hunger Is Lower and Weight Loss Is Greater in Overweight Premenopausal Women Consuming a Low-Carbohydrate/High-Protein vs High-Carbohydrate/Low-Fat Diet, The Journal of Pediatrics: Vol 105, Issue 9: 1433“1437; September 2005. http://www.sciencedirect.com/science/article/pii/S000282230501151X.


Steve, thank you for the amazing article! Your style of writing was so funny and easy to follow, and had me actually laughing out loud so many times! Low carb is the only diet that has ever worked for me. I freaking love it. I got away from it, though, and started eating too much sugar again. My daughter is getting married next year, and I have to squeeze this badonkadonk into a cute dress next year, hopefully without looking like a mama hippo, so low carb it is. I see the basic program is the same, but there have been some advancements with the science of the diet which is great. I'm excited to get at it! Today is day 1 for me. Wish me luck; I'm going in¦..
Christopher D. Gardner, PhD; Alexandre Kiazand, MD; Sofiya Alhassan, PhD; Soowon Kim, PhD; Randall S. Stafford, MD, PhD; Raymond R. Balise, PhD; Helena C. Kraemer, PhD; Abby C. King, PhD, œComparison of the Atkins, Zone, Ornish, and LEARN Diets for Change in Weight and Related Risk Factors Among Overweight Premenopausal Women, JAMA. 2007;297(9):969-977. http://jama.jamanetwork.com/art icle.aspx?articleid=205916.

Here's the Knowledge Stage analogy: Say we are hungry and want to go out to eat. It wouldn't make much sense to sprint to the nearest restaurant, right? Wouldn't we be better served to take the few minutes to learn about what's available, and then make a plan? Yes, we would take the time to Yelp or ask a friend for some knowledge and use that information to decide where we want to go.
I've always heard that the brain functions well on ketones. Gluconeogenisis typically reduces ketosis, though as well? This is the first time I've heard anyone say the brain can't use anything but glucose. I know there's *preferred* sources of fuel over others, but I was also fairly certain other sources were fine.. or humans might be in a bit of trouble.

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